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Apl. Prof. Dr. Frank Sönnichsen, Academic staff

Academic staff | Institute of Organic Chemistry

Apl. Prof. Dr. Frank Sönnichsen (Germany)

PhD Christian-Albrechts-Universität zu Kiel
Research area Spectroscopy
Scientific Education

1989
PhD (Dr. rer. nat.) in Organic Chemistry, minors Physical Chemistry and Toxicology, Christian-Albrechts-Universität zu Kiel, Germany

1985
Diplom (Master's degree) in Chemistry, CAU Kiel

1982
Vordiplom (Bachelor's degree) in Chemistry, CAU Kiel

Scientific experience

Since 2010
Professor of Chemistry, Otto Diels Institute for Organic Chemistry, University of Kiel

Since 2008
Director, Spectroscopy group, Otto Diels Institute for Organic Chemistry, University of Kiel

Since 2008
Adjunct Associate Professor, Department of Physiology and Biophysics, Case Western Reserve University

2002 - 2007
Associate Professor, Department of Physiology and Biophysics, Case Western Reserve University

2000 - 2007
Director of NMR facilities, Cleveland Center for Structural Biology

1995 - 2002
Assistant Professor, Department of Physiology and Biophysics, Case Western Reserve University

1992 - 1995
Research Associate at the Protein Engineering Network Centres of Excellence, University of Alberta

1989 - 1992
Post-doctoral Fellow with Prof. Brian Sykes, Dept. of Biochemistry, University of Alberta

Selected publications

2011
S. Venkataramani, U. Jana, M. Dommaschk, F.D. Sönnichsen, F. Tuczek, R. Herges, Magnetic Bistability of Molecules in Homogeneous Solutions at Room Temperature’, Science 331, 445-448.

2009
W.D. Van Horn, H-K Kim, C.D. Ellis, A. Hadziselimovic, E.S. Sulistijo, M.D. Karra, C Tian, F.D. Sönnichsen, CR Sanders, Solution NMR Structure of the Membrane-integral DAGK Kinase, Science 324, 1726-1729.

2008
N. Holland, S. Tsuda, F.D. Sönnichsen, ‘Two domains of RD3 Antifreeze Protein Diffuse Independently’, Biochemistry 47, 5935-5941.

2007
N.J. Cobb, FD Sönnichsen, H. Mchaourab, W.K. Surewicz, ‘Molecular architecture of human prion protein amyloid, Proc. Nat. Acad Sci., 104, 18946-18951.

2000
Y. Zhang, W. Swietnicki, M.G. Zagorski, W.K. Surewicz, F.D. Sönnichsen, 'Solution Structure of the prion protein variant associated with familial Creutzfeld Jakob disease', J Biol Chem 275, 33650-33654.

1997
H. Chao, P.L. Davies, R.S. Hodges, M. Houston, C.M. Kay, M.C. Loewen, B.D. Sykes, F.D. Sönnichsen, ‘A diminished role for hydrogen bonds in antifreeze protein binding to ice?’ Biochemistry 36, 14652 – 14660.

1996
F.D. Sönnichsen, C.I. DeLuca, P.L. Davies, B.D. Sykes, ‘Refined solution structure of Type III Antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction’, Structure 4 (15), 1325-1337.

1996
P. Lavigne, F.D. Sönnichsen, C.M. Kay, R.S. Hodges, ‘On the importance of the interhelical salt-bridges to coiled-coil stability and specificity of dimerization’, Science 271, 1136-1137.

1993
F.D. Sönnichsen, H.L. Chao, P.L. Davies, B.D. Sykes, ‘The Nonhelical Structure of Type III Antifreeze Protein’, Science 259, 1154-1157.

1992
F.D. Sönnichsen, J.E. Van Eyk, R.S. Hodges, B.D. Sykes, ‘Effect of Trifluoroethanol on Protein Secondary Structure: An NMR and CD Study using a Synthetic Actin Peptide’, Biochemistry 31, 8790-8798.

View full list of publications.

Theses 
(co-)supervised

Hauke Kobarg: Design, Synthesis and Characterization of photoactivatable antifreeze proteins

Michael Hake: Characterization of the SH3 domains of the adaptor protein Nck-1 with the juxtamembrane (JX) region of the epidermal growth factor receptor (EGFR) by NMR

Kiattawee Choowongkomon: Structure and Interactions of the juxtamembrane domain of the epidermal growth factor receptor

Pranav Dalal: Computational modeling of antifreeze protein-ice interactions

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