1994 - 1998
Junior Faculty ‘Oberarzt’, Dept. Gastroenterology, Charité Berlin.

1987 - 1994
Training in Internal Medicine/Gastroenterology, Univ. Hospital Hamburg.

1981 - 1987
Study of Medicine at University of Hamburg, San Diego and Boston.

Since 2009
W3 Professor Internal Medicine, Director Dept. of Internal Medicine I, Acting Director ICMB

2004 - 2009
C4 Professor, Director Institute of Clincial Molecular Biology Section Director, Hospital for General Internal Medicine Managing Director, Interfacultary Centre for Molecular Biosciences.

1998 - 2004
C3 Professor, Internal Medicine/Gastroenterology, Medical Faculty, CAU.

1988 - 1991
PostDoc at Washington Univ., St. Louis, MO (cell biology) and Univ. of Pennsylvania, Philadelphia, PA (Gastroenterology). Important prizes/ functions:

Since 2007
Speaker, Excellence Cluster Inflammation at Interfaces

Since 2001
Speaker, project committee German National Genome Research Network (NGFN).

1998
Gülzow Prize, German Society for Gastroenterology and Metabolism (DGVS).

1995
Frerichs Prize, German Society for Internal Medicine (DGIM).

Projects:
Since 2000

• BMBF National Genome Research Network Project Coordination and Project on the genetic etiology of Crohn's disease
• BMBF - National Genome Research Network (Environment Network, National Genotyping Platform, Population Biobank [popgen])
• BMBF - explorative project ‘longevity’
• BMBF - D-GRID (subproject)
• BMBF - Molecular Nutrition (subproject)
• BMBF - German Human Genome project (DHGP)
• BMBF - Competence Network ‘IBD’
• DFG - SFB 877: Subproject B9 Genetic variants in protein degradation pathways: from normal population variability to altered inflammatory responses in the intestinal tract
• DFG - SFB 415
• DFG - SFB 679
• DFG - SFB 617 (Rosenstiel)
• DFG - FOR 423 ‘Polygenic Disease’
• DFG - GRK820 (Antioxidants)
• EU - 5th FP (RTD and training network)
• EU - 6th FP (IP GEHA)

2011
Lepage P, Haesler R, Spehlmann ME, Rehman A, Zvirbliene A, Begun A, Ott S, Kupcinskas L, Dore J, Raedler A, Schreiber S: Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis. Gastroenterology 2011, in press

2011
Billmann-Born S, Lipinski S, Böck J, Till A, Rosenstiel P, Schreiber S: The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease. Eur J Cell Biol. 90: 593-602

2010
Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH; IBSEN study group, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S: Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet 42: 292-4

2010
Caliebe, A., Kleindorp, R., Blanché, H., Christiansen, L., Puca, A. A., Rea, I. M., Slagboom, E., Flachsbart, F., Christensen, K., Rimbach, G., Schreiber, S., Nebel, A.: No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis. Ageing Res Rev 9: 238-244.

2010
Möller, M., Flachsbart, F., Till A, Thye T, Horstmann RD, Meyer CG, Osei I, van Helden PD, Hoal EG, Schreiber S., Nebel A.**, Franke A.**: A functional haplotype in the 3’UTR of TNFRSF1B is associated with TB in two African populations. Am J Respir Crit Care Med 181: 388-393.

2010
Flachsbart, F., Caliebe, A., Nothnagel, M., Kleindorp, R., Nikolaus, S., Schreiber, S., Nebel, A.: Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals. Eur J Hum Genet 18: 59-61.

2009
Nebel, A., Flachsbart, F., Till, A. Caliebe, A., Blanché, H., Arlt, A., Häsler, R., Jacobs, G., Kleindorp, R., Franke, A., Shen, B., Nikolaus, S., Krawczak, M., Rosenstiel, P., Schreiber, S.: A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians. Mech Ageing Dev 130: 691-699.

2009
Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., Nebel, A.: Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 106: 2700-2705.

2008
Rosenstiel, P., Derer, S., Till, A., Häsler, R., Eberstein, H., Bewig, B., Nikolaus, S., Nebel, A., Schreiber S.: Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes. Genes Immun 9: 103-114.

2008
Franke, A., Fischer, A., Nothnagel, M., Becker, C., Grabe, N., Till, A., Lu, T., Müller-Quernheim, J., Wittig, M., Hermann, A., Balschun, T., Hofmann, S., Niemiec, R., Schulz, S., Hampe, J., Nikolaus, S., Nürnberg, P., Krawczak, M., Schürmann, M., Rosenstiel, P., Nebel A., Schreiber S.: Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. Gastroenterology135: 1207-1215.

2008
Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH; Mathew CG, Schreiber S: Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 40: 1319-23

2007
Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Fölsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S: A genome-wide association scan of non-synonymous SNPs identifies a susceptibility variant for Crohn disease in the autophagy-related 16-like (ATG16L1) gene. Nat Genetics 39: 207-11

2007
Schreiber S, Khaliq-Kareemi M, Lawrance IC, Østergaard Thomsen O, Hanauer SB, McColm J, Bloomfield R, Sandborn WJ (2007) Certolizumab Pegol Maintenance Therapy for Crohn’s Disease. New Engl J Med 357: 228-238

2006
Flachsbart, F., Croucher, P. J. P., Nikolaus, S., Hampe, J., Cordes, C., Schreiber, S., Nebel, A.: Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. Exp Gerontol 41: 98-102.

2005
Nebel, A., Croucher, P., Stiegeler, R., Nikolaus, S., Krawczak, M., Schreiber, S.: No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Proc Natl Acad Sci USA 102: 7906-7909.

2005
Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S: Sarcoidosis is associated with a truncating splice site mutation in the BTNL2 gene. Nat Genetics 37: 357-64

1999
Schreiber S, Nikolaus S, Hampe J, Hämling J, Koop I, Groessner B, Lochs H, Raedler A: Tumor Necrosis Factor-? and Interleukin 1ß in Relapse of Crohn’s Disease. The Lancet 353: 459-461

2010
Thomas Merkel: Molekularer Nachweis der TM7 Bakteriensubspezies bei chronisch entzündlichen Darmerkrankungen

2007
Hermann Albrecht Schulze: Untersuchung zur Identifizierung weiterer krankheitsrelevanter Gene in der Pathogenese de chronisch entzündlichen Darmerkrankungen mit Hilfe genomweiter Expressionsanalyse

2006
Andrea Nicola Titz: Genetische Varianten im E-Cadherin Gen (CDH1) als Risikofaktor für die Entstehung von primären Lymphomen des Magens

2006
Holger Erwin Kristen: Einfluss einer probiotischen Mischkultur (BB12 und LA5) in einer Fruchtmatrix auf das gastrointestinale Wohlbefinden vor, während und nach einer antibiotischen Therapie und auf die Aktivität von Helicobacter pylora

2006
Rieke Stiegeler: Untersuchung von genetischen Polymorphismen im mikrosomalen Triglyceridtransfer Protein-Gen auf eine Assoziation mit Langlebigkeit

Further dissertations supervised in the Institute of Biology